B cell memory: understanding COVID-19

Understanding B Cell Biology

Humoral autoimmunity reflects failures in B cell tolerance and regulation. Accordingly, B cells have long been proposed as targets for treating autoimmune disease. The last decade has witnessed substantial growth in the number of therapeutic agents that target B cells themselves, or molecules key to B cell survival or function. In order to understand, develop, and eventually predict the outcome...

Does a cell protein explain Covid-19 severity

Does a protein on the surface of some of our cells explain why certain people are more at risk from covid-19? The coronavirus attaches to a receptor protein on the surface(ACE) of our cells to gain entry to them. The protein is carried by cells in the nose, lungs and gut. It is possible that variation in how much of this protein people have may help explain why some are more likely to die from ...

Demographic science aids in understanding the spread and fatality rates of COVID-19

Governments around the world must rapidly mobilize and make difficult policy decisions to mitigate the coronavirus disease 2019 (COVID-19) pandemic. Because deaths have been concentrated at older ages, we highlight the important role of demography, particularly, how the age structure of a population may help explain differences in fatality rates across countries and how transmission unfolds. We...

Antigen-Specific B Cell Memory

The mechanisms that regulate B cell memory and the rapid recall response to antigen remain poorly defined. This study focuses on the rapid expression of B cell memory upon antigen recall in vivo, and the replenishment of quiescent B cell memory that follows. Based on expression of CD138 and B220, we reveal a unique and major subtype of antigen-specific memory B cells (B220(-)CD138(-)) that are ...

Pro - B / Pre - B Transition Development . II . CD 19 Facilitates the CD 19 Function in Early and Late B Cell